According to the CoinDesk Indices interview, digital assets like BTC and ETH offer a superior risk-reward ratio, with bitcoin outperforming the S&P 500 by more than three to one for incremental risk. The transparency of public blockchains and efficiency gains from DeFi reduce reliance on intermediaries, while improved infrastructure such as MPC wallets enhances security and adoption. For trading alpha, strategies include dollar-cost averaging into a portfolio of assets like ETH and trend investing based on adoption data, tech progression, and monthly signals. The HD CoinDesk Acheilus Fund leverages indices like the CoinDesk 20 to shift between crypto and cash using quantitative signals, targeting institutional investors with compliance-focused management.